Findings reveal that tenotomy reduces signaling pathways and heterotopic ossification in MRL/MpJ mice compared to C57BL/6J mice.
These findings indicate that MRL/MpJ mice possess limited capacity to regenerate injured tendons after complete rupture, and that tenotomized Achilles tendons of MRL/MpJ male mice have lesser induction of heterotopic ossification and lower activation of the signaling pathways also induced with injury in C57BL/6J male mice.
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Tang et al. (2025) studied this question.
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