Population
Adult MRL mice and C57BL/6 mice subjected to severe transmural, cryogenically induced infarction of the…
Comparison
MRL mouse strain genetic background vs C57BL/6 mouse strain
Design
Preclinical
Follow-up
60 days
Authors
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Does not alter clinical MI management; leaves open whether MRL-like regeneration can be induced in humans.
The MRL mouse strain demonstrates an extraordinary capacity for myocardial regeneration and functional restoration following severe right ventricular infarction, resembling amphibian regenerative processes.
Leferovich et al. (2001) studied this question.
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