Key result
Review summarizes current approaches and progress in improving adult heart regeneration after myocardial damage.
This review summarizes current basic research approaches and progress in inducing heart regeneration after myocardial damage.
Does not alter clinical practice; leaves open translation of regenerative approaches to adult myocardial repair.
Heart regeneration remains a critical question in current basic research and clinical practice. The adult mammalian heart exhibits a very limited regeneration capacity. In contrast, adult zebrafish and neonatal mice retain a remarkable ability of heart regeneration after damage. Understanding the mechanisms of heart regeneration would be very valuable to help design efficient treatment strategies against myocardial damage and heart failure. While inherent regeneration of the heart occurs after damage with varying efficiency among species, regeneration may also be induced exogenously. In this study, we briefly review the different approaches and current progress in improving heart regeneration.
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Cui et al. (2018) conducted a review in Myocardial damage and heart failure. Heart regeneration approaches was evaluated. This review summarizes the different approaches and current progress in improving heart regeneration after myocardial damage in adult mammals.
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