Why the study?
Adult mammalian hearts have limited regenerative ability after myocardial infarction, whereas lower vertebrates can regenerate cardiac tissue.
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Design
Review
Insights from lower vertebrate regeneration may guide post-MI strategies; leaves open translation to adult mammalian hearts.
Cardiovascular diseases are the leading cause of death worldwide, among which ischemic heart disease is the most representative. Myocardial infarction results from occlusion of a coronary artery, which leads to an insufficient blood supply to the myocardium. As it is well known, the massive loss of cardiomyocytes cannot be solved due the limited regenerative ability of the adult mammalian hearts. In contrast, some lower vertebrate species can regenerate the heart after an injury; their study has disclosed some of the involved cell types, molecular mechanisms and signaling pathways during the regenerative process. In this 'two parts' review, we discuss the current state-of-the-art of the main response to achieve heart regeneration, where several processes are involved and essential for cardiac regeneration.
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Castillo-Casas et al. (2023) studied this question.
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