What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

December 8, 2025Neurological Research and PracticeOpen Access

Paraneoplastic Lambert–Eaton myasthenic syndrome associated with non-small cell lung cancer: data from the European LEMS registry and systematic review

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Authors

HPHannah PreßlerGerman Center for Neurodegenerative Diseases CDClaire DaughertyMacula Vision Research Foundation VPVille PostilaUniversity of Eastern Finland

Discussion

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Implication

Retrospective analysis shows clinical phenotype of pLEMS varies in non-small cell lung cancer and other tumors, highlighting the need for extended screening.

Key Points

The clinical phenotype of pLEMS shows significant variation across different tumor types, including non-small cell lung cancer.
Ataxia was more frequent in patients with SCLC-pLEMS and non-SCLC-pLEMS than in aiLEMS, with statistical significance.
A systematic review identified additional cases of non-SCLC-pLEMS, raising awareness of its diverse tumor associations.
Improvement of symptoms was often linked to tumor-directed therapy, suggesting a need for timely management in diverse malignancies.

Cite This Study

Preßler et al. (2025) studied this question.

synapsesocial.com/papers/69401f142d562116f28fa436 https://doi.org/10.1186/s42466-025-00453-5

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Implication

Retrospective analysis shows clinical phenotype of pLEMS varies in non-small cell lung cancer and other tumors, highlighting the need for extended screening.

Paraneoplastic Lambert–Eaton myasthenic syndrome associated with non-small cell lung cancer: data from the European LEMS registry and systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

Paraneoplastic Lambert–Eaton myasthenic syndrome associated with non-small cell lung cancer: data from the European LEMS registry and systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

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