December 8, 2025StressesOpen Access

Exploring How Reactive Oxygen Species Contribute to Cancer via Oxidative Stress

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This review uncovers how oxidative stress drives cancer and metastasis in tumor microenvironments, highlighting therapeutic resistance.

Reactive oxygen species contribute to cancer progression and therapeutic resistance in multiple contexts, pointing to their dual role in promoting and inhibiting tumor growth.
This review highlights complex interactions between oxidative stress and epigenetic reprogramming, emphasizing the importance of context in cancer biology.
Analysis of existing studies reveals gaps in understanding the role of redox-based therapies across various cancer types and their inconsistencies in clinical outcomes.
Emerging strategies for better therapies focus on real-time redox profiling and subtype-specific targeting to improve clinical translation of findings.

Tavakolpournegari et al. (2025) studied this question.

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