Chemoselective Nickel-Catalyzed Difluoromethylation of Aryl Halides with (SIPr)AgCF ₂ H as Transmetalation Reagent

Torben Rogge

doi:10.1039/d5cc06479a

December 8, 2025Chemical CommunicationsOpen Access

Chemoselective Nickel-Catalyzed Difluoromethylation of Aryl Halides with (SIPr)AgCF ₂ H as Transmetalation Reagent

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Key Points

Nickel-catalyzed difluoromethylation yielded favorable outcomes under various conditions, and with diverse aryl iodides.
This new method involves (SIPr)AgCF2H, demonstrating effective utilization as a CF2H source for the reaction.
The approach provides a user-friendly option for chemists, enhancing the accessibility of difluoromethylation processes.
Chemoselective difluoromethylation may have important applications in synthetic chemistry, particularly in creating diverse aryl compounds.

Implication

Observational analysis found nickel-catalyzed difluoromethylation in aryl halides, suggesting a user-friendly approach with (SIPr)AgCF2H.

Abstract

A user-friendly method for the difluoromethylation of aryl iodides under nickel catalysis has been developed, employing readily accessible, light- and temperature-insensitive (SIPr)AgCF 2 H as CF 2 H source. A variety of electronically diverse...

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Cite This Study

Torben Rogge (2025) studied this question.

synapsesocial.com/papers/69401f142d562116f28fa548 https://doi.org/10.1039/d5cc06479a

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Chemoselective Nickel-Catalyzed Difluoromethylation of Aryl Halides with (SIPr)AgCF ₂ H as Transmetalation Reagent

Key Points

Implication

Abstract

Discussion

Cite This Study

Chemoselective Nickel-Catalyzed Difluoromethylation of Aryl Halides with (SIPr)AgCF ₂ H as Transmetalation Reagent

Key Points

Implication

Abstract

Discussion

Cite This Study

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