A user-friendly method for the difluoromethylation of aryl iodides under nickel catalysis has been developed, employing readily accessible, light- and temperature-insensitive (SIPr)AgCF2H as CF2H source. A variety of electronically diverse arenes was smoothly transformed and the reaction displayed excellent levels of chemoselectivity, tolerating inter alia synthetically valuable triflates.
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Torben Rogge (2026) studied this question.
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