What type of study is this?

This is a In Vitro Study study.

December 8, 2025Cell Death DiscoveryOpen Access

IL-1β+ lung-resident macrophages mediate endothelial dysfunction and acute lung injury in sepsis through immune-metabolic crosstalk

View Full Paper

Ask AI

Bookmark

Authors

DYDong YangNanchang University TLTianyuan LiAnhui University of Science and Technology DLDingde LongNanchang University

Discussion

Member takes

Implication

Murine analysis reveals that IL-1β+ macrophages impair endothelial integrity, suggesting potential therapeutic targets for acute lung injury in sepsis.

Key Points

Acute lung injury is driven by IL-1β+ macrophages, causing endothelial dysfunction.
Single-cell RNA sequencing revealed pro-inflammatory features of macrophages involved in sepsis.
This study employed murine models and various techniques including metabolomics and immunoassays.
Targeting IL-1β may mitigate endothelial dysfunction and provide therapeutic opportunities for sepsis.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/69401f142d562116f28fa572 https://doi.org/10.1038/s41420-025-02868-0

View Full Paper

Ask AI

Bookmark

Implication

Murine analysis reveals that IL-1β+ macrophages impair endothelial integrity, suggesting potential therapeutic targets for acute lung injury in sepsis.

IL-1β+ lung-resident macrophages mediate endothelial dysfunction and acute lung injury in sepsis through immune-metabolic crosstalk

Discussion

Member takes

Implication

Key Points

Cite This Study

IL-1β+ lung-resident macrophages mediate endothelial dysfunction and acute lung injury in sepsis through immune-metabolic crosstalk

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider