Review reveals granzyme B-targeted PET imaging improves treatment response prediction in cancer immunotherapy, suggesting new monitoring strategies.
In the context of cancer immunotherapy, assessing treatment response and predicting survival outcomes remain major challenges. Granzyme B (GZMB), released by cytotoxic T cells, represents the terminal effector event of activated antitumor immunity, thereby providing a robust rationale for GZMB-targeted positron emission tomography (GZMB PET) imaging as a noninvasive, real-time, and dynamic approach to monitoring immune activity within the tumor microenvironment. This review aims to 1) outline the molecular and immunological mechanisms of GZMB in antitumor immunity; 2) critically appraise the clinical value of GZMB PET beyond short-term response prediction; and 3) compare GZMB PET with existing imaging and biomarker‑based strategies, delineating its advantages, limitations, and translational prospects to inform future research and clinical practice.
No takes yet. Share an insight, caveat, or question.
Xu et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: