Implementation of vancomycin area under the curve therapeutic drug monitoring with model informed precision dosing: a scoping review protocol

Objective: The objective of this review is to report, characterize, and map the strategies used to implement vancomycin area under the curve/minimum inhibitory concentration (AUC/MIC) therapeutic drug monitoring and/or vancomycin model-informed precision dosing (MIPD) in the hospital setting. Barriers to and facilitators of implementation will also be included. Introduction: Implementation of both vancomycin AUC/MIC–based therapeutic drug monitoring and vancomycin MIPD will continue to remain challenging until health care providers have the necessary suite of implementation tools available at their disposal to overcome many of the contextual barriers they currently face. To expediate the delays to implementation, a scoping review would be a useful preliminary step to collate, summarize, and present the relevant and published literature on this topic. Eligibility criteria: The proposed scoping review will consider studies describing methods or strategies that include health care workers involved in the implementation of vancomycin AUC/MIC–based therapeutic drug monitoring and/or vancomycin MIPD for methicillin-resistant Staphylococcus aureus infections. Studies that examine barriers and facilitators to implementation will also be included. Methods: This review will be conducted using JBI methodology and reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) checklist. The search strategy will include 3 databases: MEDLINE (Ovid), Embase (Ovid), and Scopus. MedNar and ProQuest Dissertations and Theses will be included for gray literature. Two reviewers will independently screen titles and abstracts, full-text documents, and conduct data extraction. Data from included studies will be extracted using a standardized template, and findings will be summarized narratively and accompanied by tables and figures. Review registration: OSF https://osf.io/e4jd2