The research demonstrates α-selective ring-opening and spirocyclization to generate spirocyclobutyl lactams without using catalysts.
A variety of spirocyclobutyl lactams were conveniently prepared by the Brønsted acid-catalyzed α-selective ring-opening of bicyclo[1.1.0]butane (BCB) within 15 min under mild conditions without any photocatalysts, oxidants, metal catalysts, or radical initiators. This reaction involved the rapid ring-opening of BCB to generate carbocation, which further efficiently promoted intramolecular Friedel-Crafts alkylation or intramolecular spirocyclization to access diverse spirocyclobutyl lactams.
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Hongwei Zhao (2025) studied this question.
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