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December 6, 2025Journal of Geriatric Psychiatry and Neurology

Patients With Older-Age Bipolar Disorder (OABD) Visiting a Memory Clinic: Differentiating Underlying Pathophysiology With MRI and Cerebrospinal Fluid Markers

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Authors

ABAlexandra J.M. BeundersCTCharlotte E. TeunissenALAfina W. Lemstra

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Overview

Observational analysis identified cognitive impairment in bipolar disorder patients, suggesting the need for better biomarkers in diagnosis.

Key Points

  • Alzheimer's Disease was diagnosed in 6 out of 29 OABD patients, showing a significant cognitive decline.
  • Lower Aβ 42 CSF concentration correlated with lower cognitive scores in OABD patients, indicating potential neurodegenerative factors.
  • Memory clinic assessments involved neuropsychological evaluations and diagnostic work-ups to reveal cognitive impairments.
  • The findings highlight the complexity of bipolar disorder-related cognitive impairment and call for comprehensive biomarker studies.

Cite This Study

Beunders et al. (2025) studied this question.

synapsesocial.com/papers/694020fd2d562116f28fb50dhttps://doi.org/10.1177/08919887251407125
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