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August 2, 2026European PsychiatryOpen Access

Cognitive Performance in Older-Age Bipolar Disorder: A Cross-Sectional Study of Anticholinergic Load and Clinical Characteristics

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Authors

SPSimone PardossiBSBrisa SoléARAndrea Ruíz

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Overview

Cross-sectional study investigates cognitive effects of anticholinergic load in older adults with bipolar disorder, suggesting clinical implications.

Key Points

  • The study aims to evaluate how anticholinergic load affects cognitive performance in older-age bipolar disorder patients.
  • Cross-sectional study with 121 euthymic or partially remitted OABD patients.
  • Cognitive performance assessed via a neuropsychological battery including attention, memory, and executive functions.
  • Associations explored using hierarchical multivariable linear regression models.
  • Interaction between CALS and DDD linked to lower visual and verbal memory scores (p = 0.04).
  • Age inversely correlated with cognitive performance across all domains (all p < 0.01).
  • More manic episodes associated with poorer attention, memory, and processing speed (all p < 0.01).

Cite This Study

Pardossi et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeb101b0468a7eeab3d6dhttps://doi.org/10.1192/j.eurpsy.2026.12247
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anticholinergic Burden and Cognitive Function, Depressive Symptoms, and Functional Performance in Individuals With Neurocognitive Disorders: Real-World Evidence2026 · 2 citations
  2. 2Anticholinergic Burden and Its Impact on Cognitive Performance and Clinical Severity in Elderly Schizophrenia Patients2026
  3. 3Patients With Older-Age Bipolar Disorder (OABD) Visiting a Memory Clinic: Differentiating Underlying Pathophysiology With MRI and Cerebrospinal Fluid Markers2025
  4. 4Anticholinergic and sedative medication use in older patients with cognitive concerns2024 · 1 citations
  5. 5The longitudinal association between anticholinergic burden and cognitive‐functional decline among older adults2026