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August 1, 2026Journal of Integrative NeuroscienceOpen Access

Anticholinergic Burden and Cognitive Function, Depressive Symptoms, and Functional Performance in Individuals With Neurocognitive Disorders: Real-World Evidence

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Authors

MSMaria SkondraLPLeonidas PapadopoulosTKTheodora Kougioumtzoglou

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Overview

Observational study examines the impact of anticholinergic burden on cognitive and functional outcomes in older individuals, suggesting potential strategies for management.

Key Points

  • This study investigates the relationship between anticholinergic burden and cognitive function, depressive symptoms, and functional performance in individuals with neurocognitive disorders.
  • Included individuals seeking care at an old-age psychiatry outpatient clinic.
  • Assessed cognitive function, depressive symptoms, and functional performance using standardized scales.
  • Performed regression and clustering analyses to explore associations between anticholinergic burden and various symptoms.
  • Significant negative association between anticholinergic burden and cognitive functions such as long-term memory (p < 0.001) and working memory (p = 0.001).
  • Higher anticholinergic burden linked to increased depressive symptoms (p < 0.001).
  • Clustering analysis revealed higher anticholinergic burden in individuals with advanced cognitive decline and severe depressive symptoms (p < 0.001).

Cite This Study

Skondra et al. (2026) studied this question.

synapsesocial.com/papers/6a6d9874e258b358b3c6be52https://doi.org/10.31083/jin51135
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The longitudinal association between anticholinergic burden and cognitive‐functional decline among older adults2026
  2. 2Anticholinergic Burden and Its Impact on Cognitive Performance and Clinical Severity in Elderly Schizophrenia Patients2026
  3. 3[Translated article] Anticholinergic burden and its relationship with cognitive impairment in a neuropsychiatric unit2026
  4. 4Association of Anticholinergic Drug Burden With Cognitive and Functional Decline Over Time in Dementia With Lewy Bodies: 1-Year Follow-Up Study2024 · 1 citations
  5. 5Anticholinergic Burden Recognition and Management in Older Hospitalised Patients2025