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May 22, 2026Farmacia HospitalariaOpen Access

Translated article Anticholinergic burden and its relationship with cognitive impairment in a neuropsychiatric unit

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Authors

MRMaria Ruiz-JuliánGPGerard Piñol-Ripoll

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Overview

Cross-sectional study evaluates anticholinergic burden and its link to cognitive impairment in neuropsychiatric unit, suggesting a need for careful prescribing.

Key Points

  • The aim is to evaluate the prevalence of anticholinergic prescriptions and their association with cognitive impairment in a neuropsychiatric unit.
  • Cross-sectional observational study with 135 patients
  • Data collected included sociodemographics, substance use, medical diagnoses, and Mini-Mental State Examination (MMSE) scores
  • Anticholinergic burden assessed using the Anticholinergic Cognitive Burden Scale and other scales, utilizing statistical analyses
  • Negative correlation between ACB burden and MMSE score (r = -0.178; p = 0.039)
  • Significant association between ACB burden and lower MMSE after adjusting for sex and age (B = -0.27; p = 0.047)
  • Findings indicate high anticholinergic prescriptions in patients with neuropsychiatric disorders, particularly those with cognitive impairment.

Cite This Study

Ruiz-Julián et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff2f5d674f7c03778b5f6https://doi.org/10.1016/j.farma.2026.04.006
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