Investigating the binding potential of the Melissa officinalis oil against Alzheimer’s targets by molecular docking and in vitro evaluations

Q: What type of study is this?

This is a In Vitro Study study.

Atiyeh Kolouei; Mohammad Barati; Mahdi Abbas-Mohammadi

doi:10.1038/s41598-025-30232-w

December 6, 2025Scientific ReportsOpen Access

Investigating the binding potential of the Melissa officinalis oil against Alzheimer’s targets by molecular docking and in vitro evaluations

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Key Points

Melissa officinalis demonstrated antioxidant activity and cytotoxicity effects on PC12 cells, indicating potential therapeutic benefits.
Cytotoxicity evaluation used MTT assays, showing variable cell survival impacted by oil compounds.
Molecular docking analysis identified the highest affinity compounds for multiple Alzheimer's targets, including acetylcholinesterase.
These findings warrant further investigation of the oil's effects and the development of novel anti-Alzheimer's therapeutics.

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Implication

Molecular docking reveals potential therapeutic compounds from Melissa officinalis for Alzheimer's, highlighting antioxidant activity and cytotoxicity in vitro.

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Cite This Study

Kolouei et al. (2025) studied this question.

synapsesocial.com/papers/6940223b2d562116f28fb805 https://doi.org/10.1038/s41598-025-30232-w

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Investigating the binding potential of the Melissa officinalis oil against Alzheimer’s targets by molecular docking and in vitro evaluations

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Investigating the binding potential of the Melissa officinalis oil against Alzheimer’s targets by molecular docking and in vitro evaluations

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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