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Inhibition of SIRPs reduces granuloma formation by preventing macrophage adhesion in human sarcoidosis tissues, suggesting a new therapeutic target.
SIRPα is robustly expressed in monocyte/macrophage lineages within human sarcoidosis tissues, and inhibition of SIRPs (ELA026) suppresses sarcoidosis granuloma formation by preventing macrophage adhesion/aggregation.
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Judson et al. (2025) studied this question.
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