What question did this study set out to answer?

Identify the target antigens of specific monoclonal antibodies and define the cellular expression pattern and physiological signaling activity of rat signal-regulatory protein (SIRP).

August 1, 1998The Journal of Immunology

Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells

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Authors

SASusan AdamsUnited States Department of Veterans Affairs LLLuc J. W. van der LaanErasmus MC EVElizabeth Vernon‐WilsonUniversity of Waterloo

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Implication

In vitro analysis demonstrates selective signal-regulatory protein expression in myeloid and neuronal cells, indicating its functional role in immune and nervous system signaling.

Key Points

Identify the target antigens of specific monoclonal antibodies and define the cellular expression pattern and physiological signaling activity of rat signal-regulatory protein (SIRP).
Conducted expression cloning to identify the target antigens of monoclonal antibodies ED9, ED17, and MRC-OX41.
Evaluated SIRP expression across immune and nervous system cell subsets and measured macrophage nitric oxide production following receptor ligation.
Expression cloning identified rat SIRP as the antigen recognized by monoclonal antibodies ED9, ED17, and MRC-OX41.
Rat SIRP was selectively expressed on myeloid lineage cells (macrophages, monocytes, granulocytes, and dendritic cells) and neurons.
Ligation of SIRP induced nitric oxide production in macrophages.

Cite This Study

Adams et al. (1998) studied this question.

synapsesocial.com/papers/6a1c35b8d54006be995fb6a3 https://doi.org/10.4049/jimmunol.161.4.1853

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Implication

In vitro analysis demonstrates selective signal-regulatory protein expression in myeloid and neuronal cells, indicating its functional role in immune and nervous system signaling.

Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Signal-Regulatory Protein Is Selectively Expressed by Myeloid and Neuronal Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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