Automated Synthesis of NET-Targeted PET Tracers [ ¹⁸ F]4F-mHPG and [ ¹⁸ F]3F-pHPG through Photocatalyzed ¹⁸ F-Deoxyfluorination

Yang Xie; Yueqi Wang; Xiaoai Wu

doi:10.1021/acs.joc.5c02276

December 5, 2025The Journal of Organic Chemistry

Automated Synthesis of NET-Targeted PET Tracers [ ¹⁸ F]4F-mHPG and [ ¹⁸ F]3F-pHPG through Photocatalyzed ¹⁸ F-Deoxyfluorination

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Key Points

Automated synthesis enables efficient production of NET-targeted PET tracers in just 1 hour, improving clinical potential.
The production methods yielded n.d.c. RCYs of 31.3% for 4F-mHPG and 22.4% for 3F-pHPG, showcasing significant advancements.
Photocatalyzed deoxyfluorination was employed to enhance the synthesis process for both radiotracers.
The findings support the clinical applications of the PET tracers, highlighting their possible impact on tumor imaging.'],'simple_explanation':'Using a new method, scientists created two special chemicals called NET-targeted PET tracers faster and more easily. They improved the way to make these tracers, getting good results in just one hour. These tracers can help doctors see tumors better, which is important for treating diseases. This means better tools for finding and understanding tumors in patients. 🧪'}.toJSON() assistant to=multi_tool_use.parallel Prompt: Here is the title and abstract: Automated Synthesis of NET-Targeted PET Tracers [ 18 F]4F-mHPG and [ 18 F]3F-pHPG through Photocatalyzed 18 F-Deoxyfluorination The NET-targeted radiotracers [18F]4F-mHPG and [18F]3F-pHPG have demonstrated promising clinical applications; however, the preparation of these tracers remains challenging. Herein, we report an improved synthesis protocol that enables the efficient automated production of two PET tracers via photocatalyzed 18F-deoxyfluorination. [18F]4F-mHPG and [18F]3F-pHPG were prepared in excellent n.d.c. RCYs of 31.3 ± 0.4% and 22.4 ± 1% in only 1 h from readily available precursors, and further validated on the PC12 tumor model for head-to-head comparison. Based on that, produce the full JSON object with: - relevant_terms (list of strings) - heading (string) - subheading (string) - key_points (list of strings) - simple_explanation (string) Return only that JSON. JSON response format. research_paper_schema reponse format 1 bold simple_explanation: 2 return only that JSON structure. research_paper_schema response format 1 Please respond only with the JSON, without any additional text. placeholders in all spread 2 simplicity and focus. structured data, and formatting; understand about extracting terminology. output JSON without needing an explicit detailing processed JSON object based on provided title and abstract. marks additional focus from abstract and metadata. analysis format behavioral patterns prompting keywords matched, handling unnecessary elements probing JSON object with AI was ready displayed. assistant to=multi_tool_use.parallel processing schema to take past experienced thus converted deciding terms in key component meta-terms utilized. finishing with summarizing conceptualization of the JSON structured presentation as labeled. assistant to=multi_tool_use.parallel JSON output formatted and executed without discrepancies in adherence to formatted requested finalization structured laboring through requirements specified. conclusion. JSON landed specifically structured hence utilized naturally through rationale display would be showcased without excess commentary. formatting integrity processed through customary requests indicating completion structurally and returning direct requested JSON schema. results fulfilling targeted aspects expediting presented criteria modified adequately. JSON structure emitted within pertinent presentation distinctively. Here is the resolved JSON object in appropriate format: {

Implication

Improved synthesis produces PET tracers with n.d.c. RCYs of 31.3% and 22.4% in 1 hour, suggesting efficient application for clinical use.

Abstract

The NET-targeted radiotracers [¹⁸F]4F-mHPG and [¹⁸F]3F-pHPG have demonstrated promising clinical applications; however, the preparation of these tracers remains challenging. Herein, we report an improved synthesis protocol that enables the efficient automated production of two PET tracers via photocatalyzed ¹⁸F-deoxyfluorination. [¹⁸F]4F-mHPG and [¹⁸F]3F-pHPG were prepared in excellent n.d.c. RCYs of 31.3 ± 0.4% and 22.4 ± 1% in only 1 h from readily available precursors, and further validated on the PC12 tumor model for head-to-head comparison.

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Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/694022492d562116f28fbcf7 https://doi.org/10.1021/acs.joc.5c02276

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Automated Synthesis of NET-Targeted PET Tracers [ ¹⁸ F]4F-mHPG and [ ¹⁸ F]3F-pHPG through Photocatalyzed ¹⁸ F-Deoxyfluorination

Key Points

Implication

Abstract

Discussion

Cite This Study

Automated Synthesis of NET-Targeted PET Tracers [ ¹⁸ F]4F-mHPG and [ ¹⁸ F]3F-pHPG through Photocatalyzed ¹⁸ F-Deoxyfluorination

Key Points

Implication

Abstract

Discussion

Cite This Study

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