What type of study is this?

This is a Pre-Registered Trial study.

December 5, 2025Hypertension

Cardiovascular-Kidney Effects of Dapagliflozin in Patients at Cardiovascular Risk With or Without Type 2 Diabetes: Results of a Randomized, Double-Blind, Placebo-Controlled Trial

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Authors

JTJosephine TseUniversity Health Network MNMassimo NardoneMount Sinai Hospital TOTosin OsuntokunMount Sinai Hospital

Discussion

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Implication

Randomized trial showed dapagliflozin improves kidney function and vascular stiffness in patients at cardiovascular risk, suggesting potential benefits in management strategies.

Key Points

Dapagliflozin reduced vascular arterial stiffness as indicated by pulse-wave velocity, pointing to cardiovascular improvements.
Participants experienced significant decreases in blood pressure and improvements in kidney function over 12 weeks of treatment.
The trial utilized a randomized, double-blind, placebo-controlled design, ensuring robust comparisons between groups.
Findings highlight the importance of evaluating dapagliflozin's cardiovascular effects in patients at varying levels of cardiovascular risk.

Cite This Study

Tse et al. (2025) studied this question.

synapsesocial.com/papers/694022492d562116f28fbd2e https://doi.org/10.1161/hypertensionaha.125.25955

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Implication

Randomized trial showed dapagliflozin improves kidney function and vascular stiffness in patients at cardiovascular risk, suggesting potential benefits in management strategies.

Cardiovascular-Kidney Effects of Dapagliflozin in Patients at Cardiovascular Risk With or Without Type 2 Diabetes: Results of a Randomized, Double-Blind, Placebo-Controlled Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Cardiovascular-Kidney Effects of Dapagliflozin in Patients at Cardiovascular Risk With or Without Type 2 Diabetes: Results of a Randomized, Double-Blind, Placebo-Controlled Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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