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December 5, 2025Hematology

Can I stop my treatment, doctor? Is MRD-guided therapy ready for prime time?

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Authors

BDBenjamin A. Derman

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Overview

Review reveals that maintenance therapy can be safely ceased in select patients, suggesting de-escalation may improve quality of life.

Key Points

  • Maintenance therapy enhances progression-free survival in multiple myeloma patients, with recent evidence supporting its cessation.
  • Prospective studies show that stopping treatment is viable for patients with sustained measurable residual disease negativity.
  • The importance of quality of life and treatment-related toxicity are key considerations in treatment decisions.
  • Future strategies focus on de-escalation of therapy based on patient responses, aiming for personalized care pathways.

Cite This Study

Benjamin A. Derman (2025) studied this question.

synapsesocial.com/papers/6940224e2d562116f28fc0fahttps://doi.org/10.1182/hematology.2025000761
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of maintenance therapy (MT) on real-world outcomes (RWO) of patients (pts) with newly diagnosed multiple myeloma (NDMM) post stem cell transplant (SCT).2024 · 2 citations
  2. 2Daratumumab (DARA) + bortezomib/lenalidomide/dexamethasone (VRd) in transplant-eligible (TE) patients (pts) with newly diagnosed multiple myeloma (NDMM): Analysis of minimal residual disease (MRD) in the PERSEUS trial.2024 · 27 citations
  3. 3Evolution of clonal hematopoiesis on and off lenalidomide maintenance for multiple myeloma2025 · 11 citations
  4. 4Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma2017 · 1,256 citations
  5. 5Single‐agent lenalidomide maintenance after upfront autologous stem cell transplant for newly diagnosed multiple myeloma: The MD Anderson experience2023 · 10 citations