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December 5, 2025BMC Medical Research Methodology3 citationsOpen Access

Trial Sequential Analysis for dichotomous outcomes – a practical guide for systematic review protocols

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CRChristian Gunge RiberholtMOMarkus Harboe OlsenSHSigurlaug Hanna Hafliðadóttir

Key Points

  • Improving reporting of meta-analysis has significant implications for systematic reviews.
  • This guide focuses on Trial Sequential Analysis for dichotomous outcomes in clinical trials.
  • Enhanced pre-registration and reporting can strengthen the validity of systematic review protocols.
  • Application of this guide may lead to more reliable meta-analysis outcomes in future studies.

Abstract

We hope this practical guide will aid in improving pre-registration and reporting of TSAs of dichotomous outcomes within systematic review protocols with meta-analysis of randomised clinical trials in the future.

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Cite This Study

Riberholt et al. (2025) studied this question.

synapsesocial.com/papers/6940224e2d562116f28fc186https://doi.org/10.1186/s12874-025-02716-w
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