C-type natriuretic peptide mitigates apoptosis in ovarian granulosa cells through the cGMP pathway independent of PKG signaling

Q: What type of study is this?

This is a In Vitro Study study.

Deng Hong; Yingjie Wu; Lei An

doi:10.1186/s13048-025-01879-w

December 5, 2025Journal of Ovarian ResearchOpen Access

C-type natriuretic peptide mitigates apoptosis in ovarian granulosa cells through the cGMP pathway independent of PKG signaling

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Key Points

C-type natriuretic peptide reduces apoptosis in granulosa cells through a PKG-independent mechanism.
This mechanism involves transcriptional downregulation of apoptosis-related pathways during in vitro maturation processes.
Inhibition of PKG may enhance oocyte quality by altering apoptotic signaling in granulosa cells.
These findings highlight the potential for optimizing in vitro maturation systems for reproductive health.

Implication

C-type natriuretic peptide suppresses apoptosis in granulosa cells, suggesting improved oocyte quality in in vitro maturation systems.

Abstract

CNP suppresses apoptosis of granulosa cells through a PKG-independent mechanism involving transcriptional downregulation of apoptosis-related pathways. PKG appears to promote, rather than mediate, apoptosis in this system. Inhibition of PKG during IVM may improve oocyte quality and provide a useful reference for optimization of in vitro maturation systems.

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Cite This Study

Hong et al. (2025) studied this question.

synapsesocial.com/papers/6940224e2d562116f28fc1c0 https://doi.org/10.1186/s13048-025-01879-w

View Full Paper

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C-type natriuretic peptide mitigates apoptosis in ovarian granulosa cells through the cGMP pathway independent of PKG signaling

Key Points

Implication

Abstract

Discussion

Cite This Study

C-type natriuretic peptide mitigates apoptosis in ovarian granulosa cells through the cGMP pathway independent of PKG signaling

Key Points

Implication

Abstract

Discussion

Cite This Study

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