Observational analysis reveals therapeutic approach to retinal neovascularization in ROP, indicating implications for treatment strategies.
PKM2 conformational dynamics represents a novel regulatory mechanism of hypoxia-induced retinal neovascularization. Transformation of PKM2 tetramers induced by DASA-58 may provide a sound therapeutic approach for neovascular diseases including retinopathy of prematurity (ROP).
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Zhu et al. (2025) studied this question.
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