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June 11, 2026BiocellOpen Access

PKM2 as a Multifunctional Immune-Metabolic Regulator: Emerging Opportunities for Targeted Cancer Therapies Using Cell-Based, Antibody, and RNA-Directed Approaches

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Authors

KGKamila GrzeleckaJGJulia GałęziewskaMedical University of LodzWKWeronika KruczkowskaMedical University of Lodz

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Implication

Review summarizes PKM2's role in cancer metabolism and immune modulation, suggesting novel therapeutic strategies.

Key Points

  • This review explores PKM2's dual roles in cancer metabolism and immune responses, highlighting potential therapeutic avenues.
  • Summarized current knowledge on PKM2 as an immunometabolic regulator
  • Discussed various therapeutic strategies targeting PKM2
  • Analyzed challenges in translating PKM2-targeted therapies into clinical practice.
  • PKM2 regulates glycolytic flux and supports anabolic processes related to the Warburg effect.
  • PKM2 influences immune cell polarization and mediates immune evasion within the tumor microenvironment.
  • Challenges such as metabolic adaptability and limited biomarkers hinder the translation of PKM2-directed therapies.

Cite This Study

Grzelecka et al. (2026) studied this question.

synapsesocial.com/papers/6a2a52d980c8f91e7f39ead6https://doi.org/10.32604/biocell.2026.083009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pyruvate Kinase M2: Function, Regulation and Targeting Therapeutics In Cancer2026
  2. 2Targeting PKM2 in cancer therapeutics: mechanistic advances and translational opportunities2025 · 7 citations
  3. 3PKM2-driven metabolic reprogramming in digestive system tumors: mechanisms, therapeutic advances, and clinical challenges2025 · 3 citations
  4. 4THE PKM2 PYRUVATE KINASE ISOFORM: THE BASIC AND TRANSLATIONAL ASPECTS IN THE CONTEXT OF THE MOLECULAR DIAGNOSIS OF HUMAN MALIGNANCIES2025
  5. 5Precision Therapeutics in Oncology: Targeting Pyruvate Kinase for Cancer Management2026