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January 1, 2025Биохимия / Biochemistry

The Pkm2 Pyruvate Kinase Isoform: The Basic and Translational Aspects in the Context of the Molecular Diagnosis of Human Malignancies

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Authors

PBP. V. Belousov

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Overview

Review highlights metabolic adaptation and biomarkers linked to PKM2 in malignant tumors, suggesting its role in molecular diagnosis.

Key Points

  • This review examines PKM2's role in cancer metabolism and its potential use in molecular diagnosis.
  • Comprehensive analysis of PKM2 biology and metabolic functions
  • Discussion of PKM2-dependent metabolic fingerprinting
  • Contextualization of PKM2 roles in human malignancies
  • Identified PKM2 as a central regulator in energy metabolism
  • Noted potential biomarkers related to PKM2 activity
  • Explored the link between PKM2 overexpression and malignant tumor adaptability

Cite This Study

P. V. Belousov (2025) studied this question.

synapsesocial.com/papers/69255731c0ce034ddc35aaddhttps://doi.org/10.7868/s3034529425040026
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Also Consider

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  1. 1Pyruvate Kinase M2: Function, Regulation and Targeting Therapeutics In Cancer2026
  2. 2Targeting PKM2 in cancer therapeutics: mechanistic advances and translational opportunities2025 · 7 citations
  3. 3PKM2 as a Multifunctional Immune-Metabolic Regulator: Emerging Opportunities for Targeted Cancer Therapies Using Cell-Based, Antibody, and RNA-Directed Approaches2026
  4. 4The dual-faced pyruvate kinase M2 in tumors: From cytoplasmic metabolic gatekeeper to nuclear transcriptional coactivator2026
  5. 5Precision Therapeutics in Oncology: Targeting Pyruvate Kinase for CancerManagement2026