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Observational analysis demonstrated regioselectivity in C-H functionalization of alkenes, suggesting potential in organic synthesis.
Monosubstituted alkenes are widely utilized in organic synthesis. Although remarkable progress has been made in chelation-assisted alkenyl C-H functionalization, monosubstituted aliphatic alkene remains a challenging target due to reactivity and selectivity issues. Herein, we report on the first sequential α/β-C-H functionalization of monosubstituted aliphatic alkenes derived from bishomoallyl amines. This protocol showed wide functionality tolerance and afforded C-H alkenylation and allylation as well as alkynylation products with excellent regio- and stereoselectivity.
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Peng et al. (2025) studied this question.
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