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December 5, 2025Cancer Cell InternationalOpen Access

Single-cell transcriptome analysis reveals regulatory programs of prognosis-associated RNA binding proteins during LIHC development

En-di Zhang Hanfei Huang

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Key Points

Findings indicate regulatory roles of RNA binding proteins in liver cancer development.
Single-cell transcriptome analysis highlights heterogeneity and pathways relevant to HCC progression.
Research reveals HDGF as a candidate oncogenic RNA binding protein in vitro, associated with splicing.
These insights may suggest new avenues for mechanistic and therapeutic exploration in liver cancer.

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Implication

Analysis identifies RNA binding proteins linked to liver cancer progression, suggesting potential therapeutic targets.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/6940225c2d562116f28fc61e https://doi.org/10.1186/s12935-025-04088-z

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