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Domino reaction achieved spiro-cyclopropyl oxindoles in 99% yield, indicating effective use of dicyanoalkenes and benzoylformates.
A P(NMe₂)₃-mediated domino reaction between dicyanoalkenes and benzoylformates has been developed. By switching between isatin-and tetralone-derived dicyanoalkenes, the protocol divergently furnishes either spiro-cyclopropyl oxindoles or α-functionalized dicyanoalkenes in up to 99 % yield under mild conditions. Gram-scale experiments and broad substrate scope highlight the synthetic utility of the transformation.
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Guangwei Wang (2025) studied this question.
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