New approach demonstrates divergent synthesis of 3-dithiocarbamyl and 3-cabamothioyl chromones, suggesting efficient use of dimethylamine.
A practical, highly atom‐economical and switchable α ‐C(sp 2 )−H (di)thiocarbamation/chromone annulation reaction for the divergent synthesis of two types of 3‐substituted chromones has been developed. A variety of 3‐dithiocarbamyl chromones and 3‐carbamothioyl chromones were constructed efficiently from readily available o ‐hydroxyphenylenaminones ( o ‐HPEs) and carbon disulfide (CS 2 ) via KIO 3 /DTBP cooperative catalytic oxidation. Notably, this transformation proceeds efficiently by recycling by‐product dimethylamine and employing equivalent amount of CS 2 . This strategy features high atom economy, mild reaction conditions, broad substrate scope, gram‐scale preparation and further derivatization.
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Wei et al. (2025) studied this question.
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