Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 5, 2025Advanced Therapeutics

Zeta Potential Changing Self‐Emulsifying Drug Delivery Systems: A Promising Approach to Improve Oral Bioavailability of BCS Class IV Drugs by Overcoming Mucus Barriers via Enhanced Mucus Permeation and Cellular Uptake

View Full Paper
Ask AI
Bookmark
Share

Authors

AAAmina ArshadMDManling DuSAShumaila Arshad

Discussion

Loading...

Member takes

Overview

Self-emulsifying drug delivery systems improve drug absorption and mucus penetration, indicating potential for BCS Class IV drug efficacy.

Key Points

  • Enhanced oral bioavailability of BCS Class IV drugs is achieved through zeta potential modifications in SEDDS.
  • Caco-2 cell studies revealed phosphorylated SEDDS significantly increased cellular uptake compared to control.
  • Development involved alcaline phosphatase for measuring phosphate release and assessing drug delivery efficacy.
  • This promising approach highlights the vital role of zeta potential in improving drug delivery systems for poor solubility.

Cite This Study

Arshad et al. (2025) studied this question.

synapsesocial.com/papers/694023c82d562116f28fcbf0https://doi.org/10.1002/adtp.202500443
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Optimizing Self-Emulsifying Drug Delivery Systems for the Oral Delivery of a Hydrophobic Ion-Paired Lysozyme Complex2026 · 2 citations
  2. 2Revolutionizing Drug Delivery: The Promise of Self-emulsifying Systems in Overcoming Bioavailability Challenges2025
  3. 3Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood plasma and plasma membranes2024 · 6 citations
  4. 4Multifunctional self-emulsifying drug delivery system: an efficient strategy for oral delivery of therapeutic peptides and proteins2025
  5. 5About the impact of medium chain fatty acids on the permeation enhancing effects of self-emulsifying drug delivery systems2026