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September 5, 2026Drug Delivery and Translational ResearchOpen Access

About the impact of medium chain fatty acids on the permeation enhancing effects of self-emulsifying drug delivery systems

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Authors

APAnnika PostinaUniversität InnsbruckLMLana MolnarUniversität InnsbruckLWLena WernerUniversität Innsbruck

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Overview

In vitro study shows medium-chain fatty acid salts increase epithelial permeation in cell models, indicating ionization state governs oral drug delivery efficiency.

Key Points

  • Evaluate how the ionization state and formulation presentation of medium-chain fatty acids influence the permeation-enhancing performance of self-emulsifying drug delivery systems (SEDDS).
  • Formulated SEDDS with caprylic acid (C8) or capric acid (C10) incorporated as free acids, pre-dispersed sodium salts, or externally added sodium salts post-emulsification.
  • Evaluated cellular uptake across Caco-2, HEK, and HeLa cell lines, alongside mucus diffusion and epithelial transport assays across Caco-2 monolayers using lucifer yellow.
  • SEDDS containing free acids increased cellular internalization by up to 2.5-fold compared to unmodified SEDDS, whereas salt formulations showed approximately 1.5-fold lower cellular association alongside improved cellular tolerability.
  • Salt-modified SEDDS improved mucus diffusion and increased lucifer yellow epithelial permeation up to 7-fold across Caco-2 monolayers for both C8 and C10, while alkyl chain length demonstrated negligible impact compared to ionization state.

Cite This Study

Postina et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4346b95aff0620ebb3fhttps://doi.org/10.1007/s13346-026-02211-9
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