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February 10, 2026International Journal of PharmaceuticsOpen Access

Excipient toxicity and tolerability in self-emulsifying drug delivery systems: insights from cell-based assays

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Authors

MSMarlene Ramona SchmidtUniversität InnsbruckMEMagdalena EnderUniversität InnsbruckMEM H EbertUniversität Innsbruck

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Overview

This research identifies the impact of excipients on cellular tolerance in SEDDS, suggesting optimal formulations.

Key Points

  • The aim is to evaluate excipient toxicity and tolerability in self-emulsifying drug delivery systems.
  • Assess physicochemical properties of various excipient components using dynamic light scattering.
  • Evaluate biological compatibility via hemolytic effects on human erythrocytes and cell viability in CaCo-2 and HEK-293 cells.
  • Investigate metabolic activity and proliferation using the MTT test.
  • Analyze structure-activity relationships across different surfactant types.
  • Saturated triglycerides offered sixfold higher cell viability compared to free fatty acids.
  • Toxicity of co-solvents correlated with their lipophilicity, impacting cellular stress.
  • PEG-based surfactants showed superior biocompatibility over fatty alcohols and sugar-based formulations.
  • Phosphatidylcholine was the most biocompatible zwitterionic surfactant, significantly reducing hemolytic activity.

Cite This Study

Schmidt et al. (2026) studied this question.

synapsesocial.com/papers/698acaad7c832249c30b9f28https://doi.org/10.1016/j.ijpharm.2026.126646
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