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December 4, 2025Angiology

NLRC5 and NF-κB Signaling: Implications for Atherosclerotic Plaque Formation in Acute Coronary Syndromes

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Authors

HYHua YangPXPan XiongHSHongfei Song

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Overview

Observational analysis reduced atherosclerotic plaque formation in acute coronary syndromes, suggesting NLRC5 silencing may regulate macrophages and inflammation.

Key Points

  • NLRC5 silencing reduced atherosclerotic plaque formation and inflammation in acute coronary syndromes.
  • In vitro analyses showed that NLRC5 knockdown decreased cytokine release and foam cell formation.
  • Assessment of NLRC5 involvement used ApoE −/− mice fed a high-fat diet and silenced for NLRC5 expression.
  • Findings highlight the potential of targeting NLRC5 for inflammation modulation in atherosclerosis.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/694023f32d562116f28fd96ahttps://doi.org/10.1177/00033197251392646
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