Steady advection–diffusion in polygonal microfluidic mixers

We present theoretical models for flow and diffusion in microfluidic polygonal mixers of arbitrary shapes. Combining work based on Boussinesq coordinates with modern methods for the calculation of the Schwarz–Christoffel transform, we present an integrated method that yields analytical solutions for both flow and concentration profiles everywhere in microfluidic mixers with arbitrary numbers of inlets. We illustrate how the problem can be reduced to a sequence of conformal maps to a known domain, where the advection–diffusion problem can be readily solved, and map back the solution to the geometry of interest. We use the method to model a number of previously published microfluidic mixer geometries, used in lipid nanoparticle synthesis, among others. The method is also applicable to other problems described by planar transport equations in polygonal domains, for instance, in groundwater flows or electrokinetics.