Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 3, 2025Critical Reviews in Oncology/HematologyOpen Access

The role of therapeutic cancer vaccines in the modern immunotherapy era: State of the art with recent progress and future challenges

View Full Paper
Ask AI
Bookmark
Share

Authors

ETEster TasselliUniversity of VeronaAZAndrea ZiviUniversity of VeronaFZFrancesca ZacchiUniversity of Verona

Discussion

Loading...

Member takes

Overview

Therapeutic cancer vaccines improve immunogenicity and safety in precision oncology, indicating a need for better validation and cost-effectiveness.

Key Points

  • Therapeutic cancer vaccines enhance immunogenicity and elicit tumor-specific immune responses, showing promise in various cancers.
  • Key strategies include nucleic acid platforms, peptide-based designs, and optimizing tumor microenvironment conditions for enhanced efficacy.
  • Research emphasizes the role of tumor mutational burden as a significant factor in immune evasion and response to therapies.
  • Combining therapeutic vaccines with chemotherapy may overcome immune resistance, signaling a necessity for optimized clinical trial frameworks.

Cite This Study

Tasselli et al. (2025) studied this question.

synapsesocial.com/papers/694025742d562116f28fdfb8https://doi.org/10.1016/j.critrevonc.2025.105068
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A new frontier in oncology: Understanding the landscape of cancer vaccines2025 · 1 citations
  2. 2Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial2024 · 250 citations
  3. 3Randomized open-label controlled study of cancer vaccine OSE2101 versus chemotherapy in HLA-A2-positive patients with advanced non-small-cell lung cancer with resistance to immunotherapy: ATALANTE-12023 · 80 citations
  4. 4Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine2020 · 10,928 citations
  5. 5Monitoring the Response of Circulating Epithelial Tumor Cells to Adjuvant Chemotherapy in Breast Cancer Allows Detection of Patients at Risk of Early Relapse2008 · 282 citations