December 3, 2025PLoS ONEOpen Access

Amino acid metabolism of the thermophilic acetogen Thermacetogenium phaeum

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Authors

YCYuzhi Cai AMAndreas Marquardt NMNicolai Müller

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Overview

Observational analysis uncovered amino acid metabolism pathways in Thermacetogenium phaeum, suggesting distinct roles for glycine and serine degradation.

Key Points

Thermacetogenium phaeum utilizes glycine and serine, primarily via glycine cleavage system and serine-converting enzymes, highlighting specific metabolic pathways.
Serine dehydratase converts serine to pyruvate and ammonia, leading to acetate production in Thermacetogenium phaeum, which is crucial for its energy yield.
The study identifies interactions with Methanothermobacter thermautotrophicus, revealing inhibition of acetate degradation following amino acid degradation.
The findings support the importance of the Wood-Ljungdahl pathway in acetogenesis, emphasizing how different substrates affect metabolic flexibility.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/694025912d562116f28fe8e9 https://doi.org/10.1371/journal.pone.0336914

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December 3, 2025PLoS ONEOpen Access

Amino acid metabolism of the thermophilic acetogen Thermacetogenium phaeum

View Full Paper

Ask AI

Bookmark

Authors

YCYuzhi Cai AMAndreas Marquardt NMNicolai Müller

Discussion

Member takes

Overview

Observational analysis uncovered amino acid metabolism pathways in Thermacetogenium phaeum, suggesting distinct roles for glycine and serine degradation.

Key Points

Thermacetogenium phaeum utilizes glycine and serine, primarily via glycine cleavage system and serine-converting enzymes, highlighting specific metabolic pathways.
Serine dehydratase converts serine to pyruvate and ammonia, leading to acetate production in Thermacetogenium phaeum, which is crucial for its energy yield.
The study identifies interactions with Methanothermobacter thermautotrophicus, revealing inhibition of acetate degradation following amino acid degradation.
The findings support the importance of the Wood-Ljungdahl pathway in acetogenesis, emphasizing how different substrates affect metabolic flexibility.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/694025912d562116f28fe8e9 https://doi.org/10.1371/journal.pone.0336914

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