December 3, 2025Open Access

Facing Methodological Regression: External Validity Failure in Large-Scale Medical Cohorts and the Case of Spurious Cancer Signals in COVID-19 Vaccine Surveillance

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Observational studies reveal spurious cancer signals post-COVID-19 vaccination, indicating external validity failures in epidemiology.

Cancer risks were inaccurately inflated due to structural bias in non-vaccinated cohorts, impacting findings.
The study highlights significant failures in external validity within recent epidemiological frameworks.
Analysis employed establishes that internal validity does not guarantee genuine biological relevance of observational data.
Failure to correct these biases may disrupt European public health and medical discourse for years to come.

Roccetti, Marco (2025) studied this question.

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