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December 1, 2025

Luteoloside ameliorates sepsis-induced acute lung injury via AMPK-ULK1 pathway-mediated autophagy.

Bo Xu Min Huang Hang Qi Cheng Liu Hongzhou Xu Liang Cai

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Key Points

Acute lung injury is reduced in sepsis with luteoloside treatment, supporting its efficacy.
Luteoloside promotes autophagy while inhibiting apoptosis, showing a positive outcome in sepsis models.
AMPK-ULK1 pathway activation facilitates autophagy and mitigates lung injury in this condition.
These findings highlight the possible therapeutic role of luteoloside in managing sepsis-related complications.

Implication

Luteoloside activates autophagy and reduces apoptosis in sepsis-induced acute lung injury, suggesting therapeutic potential.

Abstract

Overall, luteoloside activates AMPK/ULK1 signaling to stimulate autophagy, thereby inhibiting apoptosis and alleviating sepsis-induced ALI.

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Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/694027632d562116f28ffeaf https://doi.org/10.14670/hh-18-922

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