Randomized clinical trial shows no added benefits of hyaluronic acid gel on wound healing and pain after depigmentation, highlighting effective laser treatment alternatives.
HA did not confer additional benefits to promote wound healing and reduce pain in depigmentation. Diode laser is a convenient method of depigmentation that improves initial healing and decreases initial pain, with reduced bleeding. Gingival hyperpigmentation is a major esthetic issue for many individuals. Laser and scalpel treatments produce equivalent esthetic outcomes.
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Fareed et al. (2025) studied this question.
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