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This study demonstrates tumor progression via saliva in OSCC, pointing to inflammation and metabolic reprogramming as therapeutic strategies.
This study demonstrates that saliva from OSCC patients promotes tumor progression in vivo through a multifactorial mechanism involving inflammation, stromal remodeling, and metabolic rewiring. These findings highlight the tumor-promoting potential of salivary and microbial components, suggesting new avenues for diagnostic and therapeutic strategies targeting the oral microenvironment in OSCC.
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Zhang et al. (2025) studied this question.
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