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December 1, 2025Microbes and InfectionOpen Access

Exploring the Link Between Genetically Predicted Plasma Cathepsins and COVID-19: A Mendelian Randomization Study of Susceptibility and Severity

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Authors

MMM MiaoDLDa LiuHQHuiqing Qiu

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Overview

Mendelian randomization demonstrates cathepsins influence COVID-19 severity in individuals, suggesting targeting may reduce risk.

Key Points

  • Cathepsins significantly impact COVID-19 severity, implying potential therapeutic avenues.
  • Randomized analysis shows targeting specific cathepsins could alter disease outcomes in COVID-19 patients.
  • Investigation highlights the role of enzyme activity in the pathophysiology of COVID-19.
  • Further exploration needed on interventions might improve prevention or treatment efficacy for COVID-19.

Cite This Study

Miao et al. (2025) studied this question.

synapsesocial.com/papers/694028f92d562116f29015f2https://doi.org/10.1016/j.micinf.2025.105590
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic insights into the role of cathepsins in cardiovascular diseases: a Mendelian randomization study2024 · 6 citations
  2. 2Relationship between cathepsins and cardiovascular diseases: a Mendelian randomized study2024 · 5 citations
  3. 3Genetic Evidence for Causal Relationships Between Circulating Cathepsin Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study2025
  4. 4Association between cathepsins and cardiomyopathy: A Mendelian randomization study2024 · 1 citations
  5. 5The causal relationship between cathepsins and hepatocellular carcinoma risk: A Mendelian randomization study2024