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December 1, 2025Journal of Clinical MedicineOpen Access

Early Conversion to Once-Daily MeltDose® Extended-Release Tacrolimus (LCPT) in Liver Transplant Patients

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Authors

LJLeonie JochheimEssen University HospitalAHAnne HörsterUniversity of Duisburg-EssenAFAlexandra FreyUniversity of Duisburg-Essen

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Implication

Observational study shows early switch to tacrolimus improves renal function in liver transplant patients, indicating better adherence and lower adverse events.

Key Points

  • The early switch to tacrolimus was associated with improved renal function and significant decreases in liver enzymes and creatinine levels.
  • About 90% of patients experienced adverse events during the 24-month follow-up, with gastrointestinal issues noted in 28% of cases.
  • Assessment utilized an observational analysis across 100 liver transplant recipients to evaluate safety and outcomes.
  • Findings suggest that early conversion may enable better treatment adherence and mitigate adverse effects in this population.

Cite This Study

Jochheim et al. (2025) studied this question.

synapsesocial.com/papers/69402a722d562116f2901f63https://doi.org/10.3390/jcm14238530
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Switching From Immediate- or Prolonged-Release to Once-Daily Extended-Release Tacrolimus (LCPT) on Tremor in Stable Kidney Transplant Recipients: The Observational ELIT Study2024 · 15 citations
  2. 2Evaluating the conversion to extended-release tacrolimus from immediate-release tacrolimus in liver transplant recipients2021 · 10 citations
  3. 3Chronic rejection after liver transplantation: Opening the Pandora’s box2021 · 55 citations
  4. 4Cyclosporin versus Tacrolimus as Primary Immunosuppressant After Liver Transplantation:A Meta-Analysis2006 · 264 citations
  5. 5Conversion from Standard-Release Tacrolimus to MeltDose® Tacrolimus (LCPT) Improves Renal Function after Liver Transplantation2020 · 20 citations