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December 1, 2025Clinical Case ReportsOpen Access

A Case of AL Amyloidosis With Hepatomegaly as the Main Clinical Manifestation

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Authors

SDShuchen DongRLRenjun LvWWWei Wang

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Overview

Case details highlight AL amyloidosis presenting with hepatomegaly, suggesting timely chemotherapy improves prognosis.

Key Points

  • Chemotherapy improves prognosis in AL amyloidosis, with timely intervention leading to better outcomes.
  • A key feature is elevated liver enzymes (ALP/GGT), raising suspicion for diagnosis.
  • Liver biopsy serves as the gold standard for diagnosing Light chain amyloidosis, crucial for treatment planning.
  • Monoclonal antibody therapies may lead to symptom resolution in patients with hepatic amyloidosis.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/69402a722d562116f2901fd6https://doi.org/10.1002/ccr3.71640
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Mechanisms of Amyloidosis2003 · 1,933 citations
  2. 2Role of biomarkers in early diagnosis and prognosis of cardiac amyloidosis: A systematic review and meta-analysis2024 · 6 citations
  3. 3Cardiac Amyloidosis: A Narrative Review of Diagnostic Advances and Emerging Therapies2025 · 5 citations
  4. 4Improved survival with daratumumab-CyBorD compared with CyBorD as frontline therapy for AL amyloidosis2025 · 19 citations