December 1, 2025Acta Medica BulgaricaOpen Access

Predictive Power of Biomarkers in Preeclampsia in Singleton Pregnancies: A Comprehensive Review of Current Evidence and Future Directions

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Comprehensive review highlights biomarkers' predictive value in managing preeclampsia in singleton pregnancies, suggesting clinical implications.

Preeclampsia significantly increases maternal and fetal morbidity, while biomarkers help improve management strategy.
Biomarkers like sFlt-1 and PlGF show high predictive accuracy for preeclampsia onset.
In-depth analysis of current evidence and emerging biomarkers enriches understanding of preeclampsia prediction.
Ongoing research is vital to standardize biomarker use in clinical settings and enhance pregnancy outcomes.

Kirovakov et al. (2025) studied this question.

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Comprehensive review highlights biomarkers' predictive value in managing preeclampsia in singleton pregnancies, suggesting clinical implications.