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December 1, 2025Genes Brain & BehaviorOpen Access

The Drosophila SIFamide Receptor Regulates Sleep and Feeding in a Time‐Of‐Day Specific Manner

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Authors

AVAntonia VelázquezUniversitat Autònoma de BarcelonaMCMatthew F. CusickUniversity of MichiganSDSoumita DeNational Cancer Institute

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Implication

Analysis reveals SIFamide receptor affects sleep and feeding behaviors in Drosophila, indicating its role in energy balance and survival.

Key Points

  • Loss of SIFaR leads to altered sleep and feeding patterns, impacting energy regulation.
  • Mutant Drosophila exhibited reduced sleep and increased feeding during specific times, influencing their overall survival.
  • Observational analysis of SIFaR mutant flies showed heightened locomotor activity and altered survival linked to energy balance.
  • These findings emphasize the significance of SIFaR in integrating behavioral responses to circadian and homeostatic cues.

Cite This Study

Velázquez et al. (2025) studied this question.

synapsesocial.com/papers/69402a7e2d562116f2902294https://doi.org/10.1111/gbb.70043
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