What type of study is this?

This is a Pre-Registered Trial study.

Motor Unit Patterns Correlate With Severity in Symptomatic Patients With Spinal Muscular Atrophy

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Electrophysiological mapping shows altered motor unit patterns and NMJ dysfunction in SMA patients, indicating potential biomarkers for severity.

Motor unit loss and enlarged motor units were significant in patients with SMA, indicating altered neurological function.
Clinical scores correlated with motor unit changes in severity across genetically confirmed SMA patients aged 12 and up.
Electrophysiological mapping utilized compound muscle action potentials and repetitive nerve stimulation across a patient cohort of 104.
Identified NMJ dysfunction across varying severity highlights the importance of these measures as biomarkers for SMA.

Ros et al. (2025) studied this question.

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Electrophysiological mapping shows altered motor unit patterns and NMJ dysfunction in SMA patients, indicating potential biomarkers for severity.