Observational analysis unveiled a methylation change associated with cholesterol regulation in type 2 diabetes mellitus.
MGQD did not significantly affect LDLR and SR-B1 expression or gene methylation in iWAT. However, its hypoglycemic effect may be linked to cholesterol regulation in eWAT. Potential mechanisms include increased LDLR protein levels, which may enhance cholesterol uptake, and increased Srb1 methylation, which may suppress its expression and consequently reduce cholesterol efflux.
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Peng et al. (2025) studied this question.
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