Observational analysis shows RUNX1 links to fibrosis severity in systemic sclerosis, suggesting its significance in disease progression.
This study is the first to demonstrate a potential role for RUNX1 in the pathogenesis of SSc dermal fibrosis. RUNX1 is associated with more severe SSc fibrosis and is associated with a subpopulation of dermal fibroblasts implicated in fibrosis.
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Parvizi et al. (2025) studied this question.
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